| | Player |
POS
| IP | W | L | ERA | WHIP | K | BB |
| 1 |
Max Scherzer
| SP | 119 | 8 | 6 | 3.50 | 1.09 | 125 | 29 |
| |
| 2 |
Kevin Gausman
| SP | 187 | 14 | 10 | 3.68 | 1.23 | 183 | 52 |
| |
| 3 |
Chris Bassitt
| SP | 177 | 11 | 11 | 3.94 | 1.28 | 160 | 62 |
| 4 |
Jose Berrios
| SP | 193 | 13 | 11 | 4.00 | 1.23 | 165 | 53 |
| 5 |
Bowden Francis
IL-15
| SP | 156 | 10 | 10 | 4.06 | 1.18 | 145 | 45 |
| 6 |
Easton Lucas
| SP | 24 | 1 | 1 | 4.57 | 1.41 | 21 | 10 |
| 7 |
Alek Manoah
IL-60
| SP | 16 | 1 | 1 | 4.16 | 1.25 | 15 | 6 |