| | Player |
POS
| IP | W | L | ERA | WHIP | K | BB |
| 1 |
Chris Bassitt
| SP | 174 | 11 | 11 | 4.19 | 1.30 | 157 | 60 |
| |
| 2 |
Eric Lauer
| SP | 7 | 1 | 1 | 6.43 | 1.43 | 7 | 3 |
| |
| 3 |
Jose Berrios
| SP | 188 | 11 | 11 | 4.31 | 1.28 | 159 | 54 |
| 4 |
Kevin Gausman
| SP | 184 | 12 | 10 | 4.01 | 1.24 | 181 | 54 |
| 5 |
Max Scherzer
| SP | 109 | 7 | 6 | 3.88 | 1.14 | 113 | 29 |
| 6 |
Bowden Francis
IL-15
| SP | 146 | 8 | 8 | 4.19 | 1.19 | 135 | 41 |
| 7 |
Easton Lucas
| SP | 17 | 1 | 1 | 4.24 | 1.35 | 16 | 7 |
| 8 |
Alek Manoah
IL-60
| SP | 20 | 1 | 1 | 4.50 | 1.30 | 19 | 8 |